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New biomarkers to predict progression in MS

Genetic DNA
22 January 2015

While the primary and secondary progressive forms of multiple sclerosis (PPMS and SPMS) have different pathological characteristics, scientists do not know if they share common neurodegenerative mechanisms.

The authors of a recent paper in the Journal of Neurology measured cerebrospinal fluid levels of some proteins called neurofilaments in patients at the Cemcat Centre in Barcelona, from 1994 to 2008.

The cerebrospinal fluid surrounds and protects the brain and spinal cord. It can be collected by lumbar puncture and analysed to reveal aspects of the disease related to inflammation.

Neurofilaments are normally present within nerve fibres. There are two different types of neurofilament – heavy and light. When these fibres are destroyed, as happens in MS, the level of neurofilaments in the cerebrospinal fluid increases.

Several studies have shown a correlation between the level of neurofilaments and disability in MS. As such neurofilament levels were identified as possible markers of nerve fibre damage in MS patients.

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Source: MSIF (2015)