Detecting hidden MS activity: Using advanced scanning technology

Mr Samuel Klistorner

The University of Sydney, NSW

February 2025

specialisation: Neurobiology

focus area: Better treatments

funding type: Fellowship

project type: Investigator Led Research

Summary

Inflammation in the brain known as “smouldering inflammation” plays a crucial role in the progression of MS. Unlike the more visible acute inflammation, smouldering inflammation is a slow and persistent process that contributes significantly to nerve damage and disability in people with MS. Current treatments mainly target the acute episodes but do not effectively address this chronic, underlying inflammation.

Mr Samuel Klistorner and his team will develop and refine advanced imaging techniques to detect and monitor smouldering inflammation. By using advanced MRI methods, the team plans to track the subtle changes in brain lesions over time. This will help with understanding how these lesions expand and contribute to the overall progression of MS.

Additionally, the research will explore the potential of combining various diagnostic tools, such as Visual Evoked Potentials (VEP) and Optical Coherence Tomography (OCT), to create a comprehensive biomarker for smouldering inflammation. This biomarker would allow for more precise and early detection of disease progression, ultimately leading to more personalised and effective treatment plans for MS patients.

The ultimate goal is to improve the quality of life for individuals living with MS by providing better tools for diagnosis and monitoring, which can lead to more targeted and effective treatments. By advancing our understanding of smouldering inflammation and developing these innovative techniques, Mr Klistorner and his team hope to significantly impact patient care and outcomes in the fight against multiple sclerosis.

lead investigator

co-investigator

total funding

$225,000

start year

2025

duration

3 years

STATUS

Current project

Stages of the research process

Fundamental laboratory Research

Laboratory research that investigates scientific theories behind the possible causes, disease progression, ways to diagnose and better treat MS.

Lab to clinic timeline

10+ years

Translational Research

Research that builds on fundamental scientific research to develop new therapies, medical procedures or diagnostics and advances it closer to the clinic.

Lab to clinic timeline

5+ years

Clinical Studies and Clinical Trials

Clinical research is the culmination of fundamental and translational research turning those research discoveries into treatments and interventions for people with MS.

Lab to clinic timeline

3+ years

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Detecting hidden MS activity: Using advanced scanning technology