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Around 20% of people with early stage MS have joint stiffness, which increases to 80% in the later stages of the disease. More than 40% of joint stiffness in MS occurs in the ankle. Ankle joint stiffness is particularly debilitating because it prevents normal movements of the ankle, which impedes standing up and walking or causes tripping and falls. It is thought that ankle stiffness contributes to nearly half of all falls in MS. Traditional passive stretching methods have not been effective for ankle stiffness in MS.
This project will determine the effect of a specifically designed exercise-training program on ankle joint stiffness in people with MS. This project will investigate a new approach to treatment of ankle stiffness, known as eccentric exercise. Eccentric exercise works via inducing growth and remodelling of muscle fibres. This new exercise program aims to improve ankle joint stiffness, thus reducing difficulties with mobility and the risk of falls in people with MS. This in turn would improve the level of participation in activities of daily living, as well as work and productivity.
The research will also generate new knowledge about mechanisms underlying joint stiffness. While changes to the muscle and other structures within the ankle could all contribute to the loss of movements of the joint, it is not known with certainty the processes that lead to ankle stiffness in MS.
This study is recruiting participants within NSW. For more information visit the MS Trials website here.
In the first year of this grant, Dr Hoang completed a pilot study of this clinical trial with five participants with MS. Based on the preliminary data of the first 5 participants who underwent eccentric exercises, Dr Hoang and his team are confident that this specific exercise training is feasible and may be effective in improving ankle joint stiffness in people with MS. The team have learnt that most people with MS who have developed ankle joint contracture also developed a certain degree of knee hyperextension to compensate for the loss of movements in the ankle. So, knee hyperextension needs to be controlled during the training to ensure it is effective.
In the clinic, Dr Hoang has also applied this type of training in those people with MS who have developed ankle joint contracture and stiffness, consequently affecting their mobility, but could not participate in the study. All clients improved their ankle joint stiffness and mobility after five sessions. These results provide corroborative evidence that the eccentric exercise training would work in a larger group.
Dr Hoang has formed a collaboration with Australian Catholic University for this project and is supervising a PhD student to undertake this work. Dr Hoang is now recruiting for the full group of participants and expect full recruitment by the end of 2019.
Updated: 20 April 2018
Dr Phu Hoang
$160,000
2017
3 years
Past project
