Effects of increasing dietary protein in MS

associate professor laurence macia

Associate Professor Laurence Macia

University of Sydney

| Better treatments | Epidemiology | Incubator | 2021 | Investigator Led Research |
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Summary

Diet can play a role in MS, yet there is no optimal diet recommended for people with MS. Associate Professor Laurence Macia has previously identified that increased intake of dietary protein promotes the growth of gut bacteria which might be beneficial in MS. It has been shown that these bacteria influence the immune system and potentially decrease the development of inflammatory immune cells that play a role in MS.

In this project, Associate Professor Macia and her team are testing whether an increased dietary protein intake helps restore healthy bacteria in the gut, reduces the number of inflammatory cells and ultimately reduces the severity of MS.

Associate Professor Macia and her team will investigate in laboratory models of MS whether changes in dietary protein intake will 1) beneficially change the gut microbiota composition and 2) balance the immune system towards an anti-inflammatory state, which they believe will have beneficial clinical outcomes.

In the longer term, this project will hopefully lead to better dietary recommendations for people with MS and to the development of novel strategies to boost the effectiveness of current treatments. While recent studies have highlighted the "power" of nutrition on the immune system and health in general, this dietary intervention could provide an ideal strategy to safely restore immune function and improve health in people with MS, with few, if any, side effects. It is hoped that this work will provide the critical proof-of-concept that simple lifestyle changes could dramatically improve MS.

Progress to Date

In this project, Associate Professor Laurence Macia investigated how diet composition may affect the immune response and therefore may be protective in MS. Laboratory models of MS were fed diets that were either enriched in protein (high protein diet), low in protein but enriched in fat (high fat diet), or high in carbohydrates (high carbohydrate diet).

The teams’ initial hypothesis was that the high protein diet would be protective in laboratory models of MS as they found that this diet increased the gut bacteria Lactobacilli, which were previously correlated with clinical improvement. However, they found that dietary protein had no impact on the disease severity suggesting that Lactobacilli played no beneficial roles.

Interestingly, Associate Professor Macia found that diet enriched in fat and low in carbohydrates was fully protective. While 80% of the group on the control diet and high protein diet developed the disease, none in the high fat diet developed the disease.

The team also identified that the group fed a carbohydrate enriched diet developed the most severe symptoms.

Associate Professor Macia also found that the protection observed under high fat feeding conditions was paralleled with an increased proportion of anti-inflammatory cells and decreased proportion of pro-inflammatory cells.

The team are currently investigating the gut microbiota composition in laboratory models fed on the different diets.

Updated : 31 March 2022

Updated: 19 January, 2021

Stages of the research process

Fundamental laboratory
Research

Laboratory research that investigates scientific theories behind the possible causes, disease progression, ways to diagnose and better treat MS.

Lab to clinic timeline: 10+ years
Translational
Research

Research that builds on fundamental scientific research to develop new therapies, medical procedures or diagnostics and advances it closer to the clinic.

Lab to clinic timeline: 5+ years
Clinical Studies
and Clinical Trials

Clinical research is the culmination of fundamental and translational research turning those research discoveries into treatments and interventions for people with MS.

Lab to clinic timeline: 1-5 years

Grant Awarded

  • Incubator Grant

Total Funding

  • $24,911

Duration

  • 1 year

Funding Partner

  • TDM Growth Partners
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Associate Professor Anneke Van Der Walt

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Effects of increasing dietary protein in MS