In 2014, F5m+ as part of the MS Research Australia grant round, is proud to be supporting Dr Simon Murray and Mr Stanislaw Mitew, both from the University of Melbourne.
Dr Murray will be deepening our understanding of the brain-derived neurotrophic factor (BDNF), investigating its potential to promote myelin regrowth in MS. BDNF is known to enhance myelination during brain development, and his work will investigate the ability of BDNF to repair damaged myelin and restore the function of nerve cells in laboratory models of MS.
Mr Mitew will investigate the normal mechanisms for myelination that occur during brain development, and test whether the rate of myelination can be improved under normal conditions. This will then be compared to the situation under disease conditions in laboratory models of MS, aiming to test whether these mechanisms can be reactivated to enhance myelin repair. Reactivating myelin production may be an exciting new therapeutic approach to combat MS.