In people living with MS, the coating around nerves, called myelin, is attacked by the immune system. Myelin can be repaired by cells called oligodendrocytes that survive the immune attack or by recruiting support cells called oligodendrocyte progenitor cells (OPCs). However, in people living with MS, OPCs and surviving oligodendrocytes lose their ability to repair myelin and we do not understand why.
Dr Jessica Fletcher will take four approaches to learn why OPCs and oligodendrocytes no longer make myelin in MS:
By identifying why myelin repair fails in MS, Dr Fletcher and her team will build the knowledge base essential for the development and translation of effective brain repair treatments.
Updated: 22 January, 2024
Laboratory research that investigates scientific theories behind the possible causes, disease progression, ways to diagnose and better treat MS.
Research that builds on fundamental scientific research to develop new therapies, medical procedures or diagnostics and advances it closer to the clinic.
Clinical research is the culmination of fundamental and translational research turning those research discoveries into treatments and interventions for people with MS.