Upper limb weakness and fatigue are among the most common and disabling symptoms of multiple sclerosis (MS) affecting around 75% of people living with the disease. Weakness and fatigue of the arm and hand significantly impacts independence, the ability to complete daily tasks, and overall quality of life. While current treatments aim to slow disease progression, they offer little help in restoring lost strength or movement.
Dr Thorstensen’s project will test a new, non-invasive technique called paired corticospinal-motoneuronal stimulation (PCMS), designed to strengthen the communication between the brain and spinal cord. PCMS uses carefully timed electrical signals and magnetic brain stimulation to increase the responsiveness of the nerve cells in the spinal cord that control muscles (motoneurons). In previous research on spinal cord injury, PCMS has been shown to boost muscle strength by up to 50%. This study is the first to apply PCMS to people with MS.
Dr Thorstensen’s team will study this technique in individuals with mild-to-moderate MS to see whether it will increase the responsiveness of motoneurons and whether changes correlate with improved symptoms in regard to weakness and fatigue. By comparing real and mock stimulation, the team will generate early evidence that will lead to new rehabilitation tools for MS.
Ultimately, the goal is to develop PCMS into a low-cost, widely available therapy that improves motor function, reduces disability, and enhances quality of life for people living with MS.
$24,392
2026
1 year
Current project
