Mechanisms of protection from induced EAE

Dr Ian Sutton

Garvan Institute of Medical Research, NSW

| Causes and Prevention | Immunology | Project | 2006 | Investigator Led Research |


In MS immune cells called “T cells” enter the brain and regulate the inflammatory process, which is critical in the development of the pathological changes seen in MS. Our work has looked at the dynamic changes in the secretion of regulatory molecules - termed cytokines - by different subsets of T cells which occurs following migration into the brain. This work has identified that after migration into the brain, the major Th1 population of cells produce cytokines in a carefully orchestrated manner. This work challenges currently fashionable hypotheses about T cell differentiation within the brain that are based on culturing T cells in incubators for 10-14 days in conditions that are heavily manipulated by investigators.

Project Outcomes

Our work has provided an important dimension to understanding the means by which inflammation is regulated within the brain in MS and other inflammatory diseases.

Updated: 06 January, 2006


  • Dr Ian Sutton, Garvan Institute of Medical Research, NSW

Grant Awarded

  • Project grant

Total Funding

  • $100,000


  • 2 years over 2006 - 2007

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Mechanisms of protection from induced EAE