Reducing autoimmune disease development during alemtuzumab treatment

Professor Simon Broadley

Griffith University

| Better treatments | Immunology | Project | 2022 | Investigator Led Research |
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Summary

Without treatment multiple sclerosis (MS) is commonly a disabling disease. Alemtuzumab (Lemtrada®) is a proven and approved therapy for MS which is highly effective but is associated with a 30-40% risk of developing other autoimmune diseases after treatment has been administered. Alemtuzumab is a therapeutic antibody that works in MS by temporarily removing circulating immune cells. Following alemtuzumab treatment, one type of immune cell, called B cells, is restored in the blood earlier than other immune cells. Normally, B cells are controlled by another immune cell called T cells. When B cells return after alemtuzumab treatment without the controlling effect of T cells, this is thought to contribute to the risk of developing another autoimmune disease (autoimmunity).  

It has been suggested that another monoclonal antibody which targets B cells, called rituximab, might be effective in preventing autoimmunity after alemtuzumab. An early phase clinical study has suggested that adding treatment with rituximab at key time points during alemtuzumab treatment dramatically reduces the risk of developing autoimmunity.  

The aim of this clinical trial is to determine if this therapeutic approach reduces the risk of autoimmunity following treatment of MS with alemtuzumab. Dramatically reducing or removing this risk would make treatment with alemtuzumab more appealing to both people with MS and their MS care team. The alemtuzumab treatment regime of two separate courses administered a year apart makes issues such as family planning and infusion time commitments much simpler with alemtuzumab, when compared to some other MS therapies. It would also become one of the most cost-effective therapies for MS as only two brief courses of treatment are required for the majority of patients. 

Updated: 14 February, 2022

Stages of the research process

Fundamental laboratory
Research

Laboratory research that investigates scientific theories behind the possible causes, disease progression, ways to diagnose and better treat MS.

Lab to clinic timeline: 10+ years
Translational
Research

Research that builds on fundamental scientific research to develop new therapies, medical procedures or diagnostics and advances it closer to the clinic.

Lab to clinic timeline: 5+ years
Clinical Studies
and Clinical Trials

Clinical research is the culmination of fundamental and translational research turning those research discoveries into treatments and interventions for people with MS.

Lab to clinic timeline: 1-5 years

Investigator

  • Professor Simon Broadley

Co-investigator

  • Professor Pamela McCombe
  • A/Prof Jing Sun
  • A/Prof Stefan Blum
  • Dr Mike Boggild
  • Dr Joshua Barton
  • Dr Laura Clarke
  • Dr Zara Ioannides
  • Dr Andrew Swayne

Grant Awarded

  • Project Grant

Total Funding

  • $244,196

Duration

  • 3 years

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Reducing autoimmune disease development during alemtuzumab treatment