The effect of foetal cells in maternal blood on MS during pregnancy

Dr Michael Zhong

Monash University

| Causes and Prevention | Epidemiology | Genetics | Incubator | 2021 | Investigator Led Research |
SUPPORT PROJECTS WITH THIS RESEARCH FOCUS

Summary

In women with MS, we have found that pregnancy delays time to symptom onset, slows biological ageing, and protects against disability accumulation. However, the mechanisms underlying these long-term effects of pregnancy on MS outcomes are not well understood.

One possible mechanism is foetal microchimaerism (FMC), which is the presence and effect of foetal cells in the maternal blood or other tissues. Foetal cells enter the maternal blood throughout pregnancy and can remain detectable for decades thereafter. FMC may foster immune tolerance that may be beneficial in autoimmune diseases such as MS, and this could help explain the disparity in MS outcomes between women, and between sexes.

This research therefore aims to establish associations between FMC detected in the blood of women with MS, and their disability and biological ageing.

Updated: 16 November, 2021

Stages of the research process

Fundamental laboratory
Research

Laboratory research that investigates scientific theories behind the possible causes, disease progression, ways to diagnose and better treat MS.

Lab to clinic timeline: 10+ years
Translational
Research

Research that builds on fundamental scientific research to develop new therapies, medical procedures or diagnostics and advances it closer to the clinic.

Lab to clinic timeline: 5+ years
Clinical Studies
and Clinical Trials

Clinical research is the culmination of fundamental and translational research turning those research discoveries into treatments and interventions for people with MS.

Lab to clinic timeline: 1-5 years

Investigator

Co-investigator

Grant Awarded

  • Incubator Grant

Total Funding

  • $25,000

Duration

  • 1 year

Read More

Newsletter subscription

  • Enter your details

The effect of foetal cells in maternal blood on MS during pregnancy