Tracking safety and markers of response to Cladribine treatment

dr david tscharke

Professor David Tscharke

Australian National University, ACT

| Better treatments | Immunology | Incubator | 2020 | Investigator Led Research |


All treatments for MS come with potential side effects as well as benefits. One of the downsides of these medications is that they can dampen the immune response, thereby increasing the risk of infection. Another issue with MS treatment is that it is difficult to know whether a medication is working or not until someone has a relapse.

Everyone responds to MS medications differently so an important research goal is to devise a method for early identification of response to treatments: both suppression of MS activity, and infection.

In this project Professor Tscharke and his team are looking at people treated with the disease modifying therapy Cladribine. This treatment works by temporarily reducing several cell types in the immune system. Professor Tscharke will analyse RNA in the blood of people with relapsing remitting MS treated with Cladribine. RNA is genetic material made by the DNA in cells, and it shows how these cells are responding. Viruses and bacteria also use RNA, so by looking at the RNA in people’s blood, this group will be able to simultaneously track how the immune system is functioning and the presence of infections.

This is a novel approach, and hopefully will pave the way for better methods to analyse RNA in MS studies. Importantly, it will determine whether there is increased level of bacterial and viral infection in response to therapy, and aims to identify failure of therapy for an individual long before this results in disease relapse.

Updated 21 October 2020

Updated: 21 January, 2020

Stages of the research process

Fundamental laboratory

Laboratory research that investigates scientific theories behind the possible causes, disease progression, ways to diagnose and better treat MS.

Lab to clinic timeline: 10+ years

Research that builds on fundamental scientific research to develop new therapies, medical procedures or diagnostics and advances it closer to the clinic.

Lab to clinic timeline: 5+ years
Clinical Studies
and Clinical Trials

Clinical research is the culmination of fundamental and translational research turning those research discoveries into treatments and interventions for people with MS.

Lab to clinic timeline: 1-5 years

Grant Awarded

  • Incubator Grant

Total Funding

  • $25,000


  • 1 year

Funding Partner

  • Berwick & District Dressage Club
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Tracking safety and markers of response to Cladribine treatment