Why is your research important and how will it influence the understanding and treatment of MS?
Associations between macronutrient intake and MS (limited evidence) have been investigated using conventional approaches focusing on single macronutrient intake or a handful of dietary attributes/patterns, without considering the main and interactive effects of macronutrients - a possible reason for mixed conclusions and messages. The geometric framework for nutrition (GFN) is a state-space approach to nutrition that deals with dietary complexity by considering multiple dimensions of macronutrient intake simultaneously. GFN has been successfully applied to investigate associations between macronutrients and various health and disease outcomes in mice and humans, but no studies have been conducted in relation to MS onset and disease course. Using GFN, this project will investigate the interrelated associations between macronutrient intake, quality of macronutrients, energy intake, overweight/obesity and MS onset and disease course. Therefore, my research will generate high quality evidence to support the development of guidance regarding macronutrient composition of diet for people with MS.