Investigating blood levels of hormones in people with MS

Dr Mark Stein

Royal Melbourne Hospital and Walter and Eliza Hall Institute of Medical Research, VIC

January 2013

specialisation: Immunology

focus area: Causes and Prevention

funding type: Incubator

project type: Investigator Led Research

Summary

Dr Stein and colleagues will investigate hormones in the blood in relapsing remitting MS. This pilot study will examine levels of particular hormones in the blood of people with MS and compare them with measurements taken from healthy controls. If hormonal dysfunction is found to be a hallmark of relapsing remitting MS, this project may help explain one of the mechanisms that underlie the disease process. If this proves to be a feature of the disease, levels of blood hormones could also provide biomarkers for the future development of MS. Biomarkers would be particularly useful, for example, to identify people most at risk for developing MS and to target prevention strategies.

Progress

This proof of concept study aims to determine the relationship between hormones in the blood and the severity of relapsing remitting MS. At this stage, the research team has run extensive assays to measure the hormones of interest, and statistical analysis of the results has commenced.

Further work in 2014 will explore whether circulating blood levels of hormones, including vitamin D, thyroid hormones, growth factors and homeostatic regulators, are higher in people with relapsing remitting MS; and whether the metabolic interactions among these hormones are also disturbed. Altered blood levels of these hormones may provide insight into the mechanisms of MS as many of these hormones have effects on the immune system. These hormones may also represent a useful ‘marker’ of MS if they can reliably distinguish between people with or without MS.

Updated: 30 June 2014

lead investigator

Dr Mark Stein

total funding

$24,560

start year

2013

duration

1 year

STATUS

Past project

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Investigating blood levels of hormones in people with MS