Case of PML

The pharmaceutical sponsor of Gilenya (fingolimod), Novartis, has this week reported one case of Progressive Multifocal Leukoencephalopathy (PML) in an individual currently being treated with Gilenya in Europe.

Novartis reports that over 119 000 people around the world have been treated with Gilenya.

This current case is complicated by the individual also receiving treatment for other concurrent illnesses in addition to MS, and it is not yet clear the extent to which Gilenya has contributed to this event.

Progressive multifocal leukoencephalopathy (PML) is a rare and potentially fatal viral brain infection characterised by progressive damage to the white matter of the brain. It is caused by the JC virus (JCV), which is present in about half of the general population, but only manifests in people whose immune system has been suppressed, including those on immunosuppressive medication. PML in people with MS is known to be a relatively rare safety risk of natalizumab treatment, with most cases of PML occurring after more than two years of natalizumab treatment.

This event should not be a cause for alarm in people currently taking Gilenya, and it is very important that people should not make any changes to their current medication regimen without first seeking medical advice. If you have any concerns about your current treatment plan, please speak to your neurologist.


MS Australia joins with international counterparts to commit to a shared global research strategy to accelerate cures for MS

MS Australia, together with Multiple Sclerosis organisations from Canada, Denmark, France, Germany, Italy, MS International Federation, Spain, U.K., and the U.S. have jointly declared their collective commitment to a global research strategy to cure MS.

New campaign shines light on life-changing MS Nurse Care

MS Australia has today launched a new campaign at Parliament House on World MS Day (30 May) to raise awareness of the crucial role played by MS Nurses.

What us to keep you in the loop? Subscribe today!

  • Enter your details

Read More

Newsletter subscription

  • Enter your details

Case of PML