A brain-healthy lifestyle for people living with MS

Ms Olivia Wills

The University of Wollongong, NSW

February 2023

specialisation: Social And Applied Research

focus area: Better treatments

funding type: Scholarship

project type: Investigator Led Research

Summary

Treatment of MS has changed dramatically over the past decade with improvements to the number of available drug therapies and timely standards for monitoring disease activity. While the initial focus is on the choice of treatment, discussions around brain-healthy lifestyle management, with referral to services that support lifestyle modifications, are suggested within three months of diagnosis. This represents a critical window for protective lifestyle interventions to delay the progression of MS and to maximise overall brain health.  

Combining treatment and lifestyle management to preserve brain tissue and optimise brain health is endorsed by the international MS Brain Health initiative. Lifestyle factors such as cardiovascular fitness, avoiding smoking and limiting the use of alcohol have been prioritised to maximise lifelong brain health for people living with MS (plwMS). Dietary guidance appears to be overlooked as an element of a brain-healthy lifestyle.  

This project will explore the role of diet in a brain-healthy lifestyle for plwMS pertaining towards advancements in understanding of the role of diet in MS disease progression, management and brain health. As no dietary guidelines have been established for plwMS, this project aims to rationalise dietary choices and behaviours from the perspectives of both consumers and specialist clinicians involved in MS care. This will allow exploration of the connection between diet and brain health and how clinicians can further support lifestyle management. Increased knowledge on this topic may lead to targeted nutrition approaches for brain health including recommendations for plwMS, their carers and their families. 

Progress

A scoping review of the literature has highlighted the significance of prioritising brain health in the management of MS, both in terms of the disease itself and lifestyle choices that people living with MS can make to maximise lifelong brain health.  

Healthcare professionals play an important role in guiding people living with MS towards brain health recommendations. As part of this study, 36 healthcare professionals were interviewed to explore their current practices and views of their professional roles in this context. Healthcare professionals perceived their role was to encompass empowerment, collaboration, and communication both with people living with MS and across disciplines. However, the study revealed that external factors such as time constraints, professional expertise, and consumer readiness largely limited lifestyle and brain health conversations between healthcare professionals and people living with MS.  

Ms Wills and her team intend to further explore these findings by looking at the real-life experience of people living with MS. They also plan to develop further guidance and resources for healthcare professionals to encourage people living with MS to live a brain-healthy lifestyle. 

publications

  • Wills O, Probst Y. Towards new perspectives: A scoping review and meta-synthesis to redefine brain health in multiple sclerosis. Euro J. Neuro. 2024: e16210. 
  • Wills O, Probst Y. Towards new perspectives: A systematic scoping review to redefine brain health in multiple sclerosis. MSMilan2023 – ePoster. Multiple Sclerosis Journal. 2023;29(3_suppl):1109-1134. P1675/3099 

Updated 31 March 2024

lead investigator

total funding

$70,000

start year

2023

duration

2 years

STATUS

Current project

Stages of the research process

Fundamental laboratory Research

Laboratory research that investigates scientific theories behind the possible causes, disease progression, ways to diagnose and better treat MS.

Lab to clinic timeline

10+ years

Translational Research

Research that builds on fundamental scientific research to develop new therapies, medical procedures or diagnostics and advances it closer to the clinic.

Lab to clinic timeline

5+ years

Clinical Studies and Clinical Trials

Clinical research is the culmination of fundamental and translational research turning those research discoveries into treatments and interventions for people with MS.

Lab to clinic timeline

3+ years

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Associate Professor Tomas Kalincik

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A brain-healthy lifestyle for people living with MS