Lifestyle clinical trial for weight loss in adults living with MS

Associate Professor Yasmine Probst

University of Wollongong, NSW

January 2024

specialisation: Social And Applied Research

focus area: Better treatments

funding type: Project

project type: Investigator Led Research

Summary

Healthy eating is a modifiable element of lifestyle that has the potential to improve symptoms and disease progression for people with MS. When people are first diagnosed with MS, they often change their food habits as a method of taking control of their disease. The information related to healthy eating for MS is inconsistent, with many fad diets being developed and promoted without appropriate support. When visiting their healthcare team, the topic of nutrition is rarely discussed. People with MS want to know what they should be eating to take control of their disease safely.

This research will target researchers who run studies that health professionals use as evidence. By ensuring that the tools used to target nutrition in studies are accurate and by guiding health professionals about the impact of nutrition for MS, we will begin to grow a more consistent flow of information to people with MS.

Studies in MS are heavily focused on single nutrients when food and patterns of eating should be targeted. This research will focus on food by creating a toolkit for health professionals and decision support tools using artificial intelligence so that people with MS can make decisions related to their eating based upon their individual circumstances.

The tools that are developed in this research program will be tested with health professionals and people with MS through two randomised trials that will provide additional support and guidance toward the importance of nutrition in the management of MS.

Progress

Professor Probst and her team have obtained ethics approval to conduct this project and are awaiting the signing of research contracts across the various study sites.  

Over the next year, Professor Probst aims to recruit staff for the trial, prepare and register a clinical trial protocol for the study and start the trial, with the intervention phase running until late 2025. 

Outcome

Professor Yasmine Probst and her team have led a major shift in how lifestyle management, particularly nutrition, is recognised in MS care. What began as a small research group has grown into a multidisciplinary team with national and international collaborations, including with the UK, Germany, and the Consortium for MS Care (CMSC) in the USA.

Early work by the team identified that much of the online dietary advice for people with MS was unreliable or unsafe. In response, they developed tools to assess diet quality, reviewed intervention strategies, and created a catalogue of over 5,700 food items to support a new dietary risk assessment tailored to MS. Their research also confirmed that many MS-promoted diets are not aligned with national nutrition guidelines.

Over time, the team broadened their focus to include other lifestyle factors like sleep and social connection. These insights shaped consensus guidelines and behaviour change strategies to support people living with MS, and also led to the development of a co-designed online portal and toolkit. This portal and toolkit are now being used in the HALT-MS clinical trial, supported by MS Australia.

In recognition of their impact, the team successfully secured additional funding through an MS Australia Project Grant to continue this work. Their findings have been presented internationally and are now embedded in clinical best practice guidelines and university curricula for health professionals in Australia. The project has also supported three PhD candidates and many Honours, Masters, and medical students; producing more than 17 published papers and significantly advancing the evidence base for lifestyle-focused MS care.

publications

  • Allogmanny, S., Stefoska-Needham, A., & Probst, Y. (2025). Exploring the Perspectives of Healthcare Consumers Towards the Integration of Nutrition in Routine Multiple Sclerosis Care: A Qualitative Study. Journal of Human Nutrition and Dietetics, 38(2). doi:10.1111/jhn.70042
  • Piscioneri, R., Zoszak, K., & Probst, Y. (2025). Development of the Australian Dietary Guidelines Adherence Tool (ADG-AT): A Food Matching Protocol. Nutrients, 17(6). doi:10.3390/nu17061071
  • Wills, O., Bradford, A., Bostick, M., Probst, Y., & Titcomb, T. J. (2025). Perceptions and Utilization of Registered Dietitian Nutritionists in Multiple Sclerosis Care: A Pilot Survey of Multidisciplinary Providers †. Nutrients, 17(3). doi:10.3390/nu17030385
  • Allogmanny, S., Stefoska-Needham, A., & Probst, Y. (2025). Healthcare professionals educational resources for multiple sclerosis-related health behaviour management: a scoping review. Disability and Rehabilitation, 47(6), 1391-1402. doi:10.1080/09638288.2024.2377821
  • Probst, Y., Sharp, M., & Zoszak, K. (2025). Health literacy demand and quality of website nutrition information for multiple sclerosis. Journal of Public Health Germany. doi:10.1007/s10389-024-02398-6
  • Wills, O., Wright, B., Greenwood, L. M., Solowij, N., Schira, M., Ma ler, J. J., . . . Probst, Y. (2024). Lifestyle management and brain MRI metrics in female Australian adults living with multiple sclerosis: a feasibility and acceptability study. Pilot and Feasibility Studies, 10(1). doi:10.1186/s40814-024-01495-3
  • Wills, O., Brischetto, D., Zoszak, K., Allogmanny, S., McMahon, A. T., Haartsen, J., & Probst, Y. (2024). Establishing consensus on lifestyle recommendations and behaviour change strategies to promote brain healthfocussed care for multiple sclerosis: A modified e-Delphi study. Multiple Sclerosis and Related Disorders, 92. doi:10.1016/j.msard.2024.105949
  • Wills, O., Manche, S., & Probst, Y. (2024). A Qualitative Exploration of the Socioecological Influences Shaping the Diagnostic Experience and Self-Management Practices Among People Newly Diagnosed With Multiple Sclerosis. Health Expectations, 27(6). doi:10.1111/hex.70091 10 / 18
  • Zoszak, K., Batterham, M., Simpson-Yap, S., & Probst, Y. (2024). Web scraping of user-simulated online nutrition information for people with multiple sclerosis. Multiple Sclerosis and Related Disorders, 88. doi:10.1016/j.msard.2024.105746
  • Probst, Y., & Kinnane, E. (2024). Quality of reporting health behaviors for multiple sclerosis (QuoRH-MS): A scoping review to inform intervention planning and improve consistency of reporting. Brain and Behavior, 14(8). doi:10.1002/brb3.3635
  • Wills, O., & Probst, Y. (2024). Towards new perspectives: A scoping review and meta-synthesis to redefine brain health for multiple sclerosis. European Journal of Neurology, 31(6). doi:10.1111/ene.16210
  • Allogmanny, S., & Probst, Y. (2024). Dietary Modification Combined with Nutrition Education and Counseling for Metabolic Comorbidities in Multiple Sclerosis: Implications for Clinical Practice and Research. Current Nutrition Reports, 13(2), 106-112. doi:10.1007/s13668-024-00538-8
  • Wills, O., Probst, Y., Haartsen, J., & McMahon, A. T. (2024). The role of multidisciplinary MS care teams in supporting lifestyle behaviour changes to optimise brain health among people living with MS: A qualitative exploration of clinician perspectives. Health Expectations, 27(2). doi:10.1111/hex.14042
  • Lechner-Scott, J., Probst, Y., Giovannoni, G., Hawkes, C. H., Levy, M., & Yeh, E. A. (2024). What is the role of diet for multiple sclerosis? Why epidemiological studies don’t give the fu l answer. Multiple Sclerosis and Related Disorders, 83. doi:10.1016/j.msard.2024.105457
  • Probst, Y., Luscombe, M., Hilfischer, M., Guan, V., & Houston, L. (2024). Exploring factors to interpretation of targeted nutrition messages for people living with multiple sclerosis. Patient Education and Counseling, 119. doi:10.1016/j.pec.2023.108039
  • Manche, S., & Probst, Y. (2023). Exploring the socio-ecological factors impacting lifestyle management of multiple sclerosis: A scoping review. Multiple Sclerosis and Related Disorders, 79. doi:10.1016/j.msard.2023.104958

Updated 31 March 2025

lead investigator

co-investigator

Associate Professor Yvonne Learmonth
Dr Litza Kiropoulos
Professor Anneke van der Walt
Dr Julie Campbell
Professor Marijka Batterham
Associate Professor Nenad Naumovski
Professor Lorna Moxham

total funding

$250,000

start year

2024

duration

4 years

STATUS

Current project

Stages of the research process

Fundamental laboratory Research

Laboratory research that investigates scientific theories behind the possible causes, disease progression, ways to diagnose and better treat MS.

Lab to clinic timeline

10+ years

Translational Research

Research that builds on fundamental scientific research to develop new therapies, medical procedures or diagnostics and advances it closer to the clinic.

Lab to clinic timeline

5+ years

Clinical Studies and Clinical Trials

Clinical research is the culmination of fundamental and translational research turning those research discoveries into treatments and interventions for people with MS.

Lab to clinic timeline

3+ years

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Lifestyle clinical trial for weight loss in adults living with MS